MIST Therapy is an advanced wound-healing modality, on the market since 2005.  It is non-contact, low-frequency, non-thermal ultrasound delivered through a saline mist. It is painless. The mechanical energy of the ultrasound penetrates tissue deeply to advance the wound to healing. It works at the cellular level, not just on the wound surface. The saline mist is simply the medium for the ultrasound energy.

MIST is nothing like traditional ultrasound or pulse lavage: there is no thermal component and no PSI, so there are no side effects. The ultrasound energy removes barriers to healing (sustained inflammation, bacteria, biofilm, and high levels of MMPs) and stimulates cells to healing (increased vasodilation and angiogenesis, early release of growth factors, increased collagen deposition). MIST can be safely used over exposed muscle, bone, tendon, nerve, blood vessel, bowel, abdomen, hardware, etc. Again, it is painless. A huge benefit is the actual significant pain reduction that occurs because of the decrease in inflammation and reduction of bacteria and biofilm.

MIST Therapy is indicated for any chronic or stalled wounds, as well as high-risk or acute wounds. These include:

  • Pressure ulcers
  • Diabetic ulcers
  • Venous or ischemic wounds
  • Surgical or trauma wounds
  • Burns
  • Deep tissue injuries
  • Highly infected wounds
  • Painful wounds
  • Atypical wounds such as pyoderma, calciphylaxis, necrotizing fasciitis 

For patients that are on wound vacs, the 2 modalities potentiate each other. MIST on days when the wound vac has dressing changes speeds the overall healing.

For patients receiving skin substitutes or grafts, MIST Therapy first for wound-bed prep results in greater acceptance of the applied skin substitute because it reduces bacteria, biofilm and sustained inflammation.

Helpful documents:

Clinical Summary

Mechanism of Action